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KMID : 0358420090520020228
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 2 p.228 ~ p.236
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The clinicopathological relationship of E2F-1 and Ki-67 expression in endometrial cancer
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Chong Hye-In
Baek Yun-Ji
Jang Ho-Jin
Suh Dong-Soo
Yoon Man-Soo
Choi Kyung-Un
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Abstract
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Objective: The aim of this study was to evaluate the correlation of E2F-1 and Ki-67 expression with clinicopathological prognostic factors.
Methods: Retrospectively, endometrial cancer slide samples (n=71) were analyzed. E2F-1 and Ki-67 were evaluated using immunohistochemical staining. And as a control (n=21), endometrial tissues were obtained by hysterectomy with benign gynecologic disease.
Results: Of 71 cases, the positive E2F-1 expression was 53.5% (38/71) in endometrial cancer. The expression of E2F-1 showed a remarkable positive correlation with myometrial invasion (P=0.001) and lymphovascular invasion (P=0.000). The Ki-67 labeling index was 30.56±25.67 in endometrial cancer and 9.38±8.35 in normal endometrial tissues (P=0.001). The Ki-67 labeling index showed positive correlations with increased tumor size (P=0.046, γ=0.238), positive lymph node metastasis (P=0.001, γ=0.396), cervical invasion (P=0.000, γ=0.404) and lymphovascular tumor invasion (P=0.000, γ=0.597). There was a positive correlation between E2F-1 and Ki-67 expression (P=0.000, γ=0.734).
Conclusion: The Ki-67 expression seems to be related with tumor invasiveness and growth in endometrial cancer and shows a remarkable positive correlation with E2F-1. The E2F-1 expression seems to be not related as a direct prognostic factor but related with tumor invasiveness and growth in endometrial cancer.
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KEYWORD
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Endometrial cancer, E2F-1, Ki-67
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